Amplification of informational social media posts are crucial for disseminating tobacco control messages as part of an integrated behavior change strategy. Our study explores the amplification effectiveness of fear-based, trust-based, and linguistically complex framing for tobacco control appeals from credible sources and in general. Analyzing 42,261 tweets from 102 accounts using natural language processing techniques, we found fear-based (38.75%) and complex appeals (31.53%) increased retweets, while trust-based decreased them (-37.28%). Credible sources amplified trust-based (58.98%) and fear-based (69.58%) appeals but reduced the amplification of complex messages (-11.01%). Consequently, we highlight the need for strategic framing of tobacco control messages for greater impact.