How negative sampling shapes the performance of transcription factor binding site prediction models

Natan Tourne et al.

Bioinformatics2026https://doi.org/10.1093/bioinformatics/btag048article
ABDC A
Weight
0.50

Abstract

The code used in this study is available at https://github.com/NatanTourne/TFBS-negatives (DOI: 10.5281/zenodo.18007567).

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https://doi.org/https://doi.org/10.1093/bioinformatics/btag048

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@article{natan2026,
  title        = {{How negative sampling shapes the performance of transcription factor binding site prediction models}},
  author       = {Natan Tourne et al.},
  journal      = {Bioinformatics},
  year         = {2026},
  doi          = {https://doi.org/https://doi.org/10.1093/bioinformatics/btag048},
}

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How negative sampling shapes the performance of transcription factor binding site prediction models

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Evidence weight

0.50

Balanced mode · F 0.40 / M 0.15 / V 0.05 / R 0.40

F · citation impact0.50 × 0.4 = 0.20
M · momentum0.50 × 0.15 = 0.07
V · venue signal0.50 × 0.05 = 0.03
R · text relevance †0.50 × 0.4 = 0.20

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