This article presents a study aimed at integrating two road safety approaches to effectively prioritise road sections requiring safety improvements. The study examines the role of injury severity assessment in evaluating the safety of road networks. It outlines the fundamental principles of the MAIS3+ methodology, discusses its relevance to road-safety analysis, and highlights its potential applications for assessing road infrastructure risk. A pilot safety assessment of the Lithuanian main road network is presented, based on the severity of traffic accident outcomes classified according to the MAIS3+ criterion. Furthermore, the study addresses the challenges of linking hospital and police data and provides recommendations to improve data integration.