This study examines the challenges faced by ready-made garment (RMG) suppliers regarding social compliance and strategies to overcome those challenges. Based on a structured questionnaire, a survey was conducted among 187 compliance/HR managers of RMG suppliers. The study identified 21 challenges under five key challenges such as organisational capability, economic and financial issues, socio-cultural barriers, and labour management issues. Out of 21 challenges, 17 were statistically significant. Besides, this study explored 11 statistically significant strategies to address these challenges. RMG suppliers, buyers, policymakers, and other stakeholder having a stake on the assurance of social compliance should design policies and regulations that facilitate and promote safe and secure workplace environment. Concerted efforts from the buyers, owners, managers, and regulators are needed to eliminate challenges by adopting the strategies.