Career resilience, which is culturally and contextually determined, has been insufficiently explored in the literature regarding women, with an inadequate investigation into the factors predicting their resilience. This investigation offers fresh insights into the determinants of career resilience among women professionals in the Indian information technology sector by examining career‐related personal cognitive factors. The study specifically explored the effects of career self‐management skills, work volition, career salience, and occupational self‐efficacy on career resilience ( N = 306). Hierarchical multiple regression analysis revealed that career self‐management skills, work volition, and occupational self‐efficacy significantly predicted career resilience in women professionals. Additional analyses revealed occupational self‐efficacy as a mediating factor. These findings contribute to formulating strategies to enhance career resilience through organizational support and targeted interventions.