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A Case for Coordinating Economic Development Planning With Energy Planning

Leighton Lord & Jeff Ruble

South Carolina Journal of International Law and Business2011https://doi.org/10.1016/j.ijbiomac.2020.10.221article
ABDC C
Weight
0.26

What the paper says

In recent years, studies on immunomodulation by surface-layer proteins (Slps) have mainly focused on Lactobacillus acidophilus, there is little information on Slp from L. crispatus and its intestinal immunomodulatory mechanisms in macrophages. In our study, the anti-inflammatory actions of Slp derived from L. crispatus JCM 2009 and its related molecular mechanisms were investigated. We initially found that incubation with Slp (5-10 μg/mL) for 4 h significantly inhibited nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production in LPS-stimulated RAW264.7 cells (P < 0.001). We then found that Slp inhibited the inflammatory response by regulating the PI3K/AKT/mTOR signaling pathway and activating autophagy in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Furthermore, ELISA and Western blotting results demonstrated that the NF-κB signaling pathway positively regulated autophagic activity to inhibit the productions of PGE<sub>2</sub> and NO during this inflammatory response. And p65 was identified as a potentially important NF-κB signaling pathway molecule mediating the effects of Slp on the LPS-induced inflammatory response in RAW264.7 cells. Our findings provide the novel perspective that Slp exerts its anti-inflammatory effects through the activation of autophagy, making it a promising bioactive ingredient for the development of functional foods.

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https://doi.org/https://doi.org/10.1016/j.ijbiomac.2020.10.221

Or copy a formatted citation

@article{leighton2011,
  title        = {{A Case for Coordinating Economic Development Planning With Energy Planning}},
  author       = {Leighton Lord & Jeff Ruble},
  journal      = {South Carolina Journal of International Law and Business},
  year         = {2011},
  doi          = {https://doi.org/https://doi.org/10.1016/j.ijbiomac.2020.10.221},
}

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A Case for Coordinating Economic Development Planning With Energy Planning

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Evidence weight

0.26

Balanced mode · F 0.40 / M 0.15 / V 0.05 / R 0.40

F · citation impact0.00 × 0.4 = 0.00
M · momentum0.20 × 0.15 = 0.03
V · venue signal0.50 × 0.05 = 0.03
R · text relevance †0.50 × 0.4 = 0.20

† Text relevance is estimated at 0.50 on the detail page — for your query’s actual relevance score, open this paper from a search result.