Interregional income inequalities have increased in several European countries, with income concentrating in metropolitan regions. This paper analyses the structural roots of these inequalities using an extended multiregional input–output model that endogenises household income and consumption. The approach identifies each region’s position in the interregional income value chains and measures the spillovers it generates and the spillovers it receives through household spending. The methodology is applied to the EUREGIO database for 2000 and 2010, which allows to uncover underlying long-standing structural asymmetries across regions that help explain the persistence of interregional inequalities.