The accelerating digital transformation of manufacturing is enhancing automation and production efficiency while requiring employees to develop new skills to meet evolving demands. This case study examines how Siemens embedded a human-centric, bottom-up approach to empower employee re- and upskilling through innovative digital learning. Aligned with Siemens’s actions, we present a four-phase model on leveraging information systems to address skill gaps, enhance adaptability and tackle re- and upskilling challenges. We also provide five recommendations to help organizations foster lifelong learning in dynamic manufacturing environments.