Academic spin-offs (ASOs) are an important channel for technology transfer in universities and are created with the participation of researchers or inventors. However, their development and market success require actions and resources from various stakeholders, making the process challenging. This study proposes a structured model for technology transfer through ASOs in public universities, using a case study at the Federal University of Mato Grosso do Sul (UFMS). The research follows the guidelines of the Soft Systems Methodology (SSM) to structure the problem and define a set of essential activities for the creation and consolidation of spin-offs. The main results include a list of key actions for implementing the process and a detailed model for creating ASOs at UFMS, aiming to strengthen innovation and academic entrepreneurship.