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Cost-effectiveness of pembrolizumab plus chemotherapy for metastatic non-small cell lung cancer: a head-to-head trial vs. real-world comparison

Srinivas Teppala et al.

Journal of Medical Economics2026https://doi.org/10.1080/13696998.2026.2651038article
ABDC C
Weight
0.50

What the paper says

Pembrolizumab plus platinum therapy is unlikely to be cost-effective for mNSCLC. The higher ICER with RWE compared to RCT data suggests that trial-based outcomes may overestimate effectiveness in routine practice. These findings highlight the importance of incorporating RWE into post-approval reassessment for high-cost oncology therapies.

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https://doi.org/https://doi.org/10.1080/13696998.2026.2651038

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@article{srinivas2026,
  title        = {{Cost-effectiveness of pembrolizumab plus chemotherapy for metastatic non-small cell lung cancer: a head-to-head trial vs. real-world comparison}},
  author       = {Srinivas Teppala et al.},
  journal      = {Journal of Medical Economics},
  year         = {2026},
  doi          = {https://doi.org/https://doi.org/10.1080/13696998.2026.2651038},
}

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Cost-effectiveness of pembrolizumab plus chemotherapy for metastatic non-small cell lung cancer: a head-to-head trial vs. real-world comparison

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Evidence weight

0.50

Balanced mode · F 0.40 / M 0.15 / V 0.05 / R 0.40

F · citation impact0.50 × 0.4 = 0.20
M · momentum0.50 × 0.15 = 0.07
V · venue signal0.50 × 0.05 = 0.03
R · text relevance †0.50 × 0.4 = 0.20

† Text relevance is estimated at 0.50 on the detail page — for your query’s actual relevance score, open this paper from a search result.