OCCUPATIONAL APPLICATIONSAs extended reality (XR) technologies continue to evolve, their use in remote collaboration and workplaces with physical limitations offers opportunities to improve ergonomics and efficiency. In this study, we explored how virtual reality (VR) and mixed reality (MR) systems impact users' sense of presence, perceived workload, object manipulation, and physiological responses in remote collaboration settings with movement constraints. We found that VR-based collaboration enhanced the sense of presence and reduced the need for physical movement compared to MR. Specifically, features such as a thumbstick button enabled teleportation in VR to help minimize physical strain. In contrast, MR systems led to higher objective and subjective measures of physical demands, suggesting greater strain and potential fatigue from ongoing physical interactions. Our findings highlight the importance of designing XR systems that balance productivity with worker well-being, particularly in environments that require physical adaptability.