This article takes college students' learning adaptability as the research object, adopts B/S structure to develop a learning adaptive platform, designs a learner data model, a learning style model, a learning resource presentation module, and an ability level test module; tests the platform through simulated data; and analyzes college students' learning style, knowledge level and learner collaboration level. The results show that college students' learning adaptation has the characteristics of flexibility, individuality, initiative, and reflection. A self-adaptive learning platform can understand its learning state and effect through learning evaluation, adjust its learning strategies and methods in time, and help college students better understand and master knowledge. The research results provide theoretical data support for the exploration of college students' learning adaptability under the background of wisdom education.