This research examines the impact of the human development index (HDI) on gross domestic product (GDP) growth in Sub-Saharan Africa. Nigeria, Kenya and Ethiopia were selected as case studies due to their economic importance and diverse development patterns within the region. Combined data models were used, with the traditional combined model being the optimal choice. The study reveals a weak positive correlation between the HDI and GDP growth, not exceeding 30%. This indicates that the HDI contributes very little to the region’s GDP growth, suggesting inadequate spending on education, health, and improving living standards in these countries. Kenya is among the best-performing countries in terms of spending. Therefore, the study recommends increasing spending on health and education and raising living standards to improve the HDI and, consequently, GDP growth.