This paper develops a multidimensional, mezzo model of uncertainty to pave the way for interdisciplinary theory development. We propose an information-processing model, where perceptions of eco-system uncertainty are shaped by its complexity, expressed by the number of elements that are embedded in it, their diversity and interconnectedness, and by the eco-system changeability in terms of degree, pace and consistency. In contrast to traditional approaches, the proposed model posits that what affects the behavior of organizational decision makers are the transient feelings of uncertainty. These feelings emanate not only from the way decision-makers perceive and interpret uncertainty triggers embedded in their environment, but also from their cognitive capabilities, epistemic motivation and tolerance for ambiguity. Implications for management and organization theories are discussed.